public string CalculateMD5Hash(string input)
{
// step 1, calculate MD5 hash from input
MD5 md5 = System.Security.Cryptography.MD5.Create();
byte[] inputBytes = System.Text.Encoding.ASCII.GetBytes(input);
byte[] hash = md5.ComputeHash(inputBytes);

// step 2, convert byte array to hex string
StringBuilder sb = new StringBuilder();
for (int i = 0; i < hash.Length; i++)
{
sb.Append(hash[i].ToString("X2"));
}
return sb.ToString();
}
An example call:

string hash = CalculateMD5Hash("abcdefghijklmnopqrstuvwxyz");…returns a string like this:

C3FCD3D76192E4007DFB496CCA67E13B